BLOC1S2 蛋白, Human (N-GST)

BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (N-GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with N-GST labeled tag.

BLOC1S2 蛋白是 BLOC-1 复合物的重要组成部分，对于溶酶体相关细胞器 (LRO)（包括血小板致密颗粒和黑素体）的正常生物发生至关重要。BLOC-1 复合物与 AP-3 复合物一起，对于将膜蛋白货物引导到细胞体形成的囊泡中至关重要，从而促进它们递送到神经突和神经末梢。BLOC-1 复合物与 SNARE 蛋白结合也参与神经突延伸。作为 BORC 复合体的一部分，BLOC1S2 可能有助于溶酶体在细胞外周的运动和定位，与溶酶体的胞质面相关联，并可能招募 ARL8B 将溶酶体与微管正端定向驱动蛋白马达偶联。此外，BLOC1S2 可能在细胞增殖中发挥作用，作为溶酶体相关细胞器复合物 1 (BLOC-1) 和 BLOC-one 相关复合物 (BORC) 生物发生的一部分，与这些复合物内的各种成分相互作用，包括 BLOC1S1、 BLOC1S3、BLOC1S4、BLOC1S5、SNAPIN 和 IFT57。

Human

E. coli

N-GST

Q6QNY1-2 (M1-R99)

282991

Full Length of Isoform-2

MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Approximately 34 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 8.0, 10% trehalose, 0.02% Tween 80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.