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BLOC1S2 蛋白, Human (N-GST)

目录号: HY-P76171A
产品使用指南 技术支持

BLOC1S2 是 BLOC-1 复合物的重要组成部分,对于溶酶体相关细胞器 (LRO)(包括血小板致密颗粒和黑素体)的生物发生至关重要。BLOC-1 与 AP-3 复合物合作,将膜蛋白货物引导至囊泡中,以递送至神经突和神经末梢,表明它参与神经突延伸。BLOC1S2 蛋白, Human (N-GST) 是重组的 BLOC1S2 蛋白,由 E. coli 表达,带有 N-GST 标签。

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规格 价格 是否有货 数量
Free Sample   Apply now  
5 μg ¥580 In-stock
10 μg ¥920 In-stock
50 μg ¥2400 In-stock
100 μg ¥3850 In-stock
500 μg ¥11500 询价
1 mg ¥18500 In-stock
> 1 mg   询价  

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描述

BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (N-GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with N-GST labeled tag.

研究背景

BLOC1S2 蛋白是 BLOC-1 复合物的重要组成部分,对于溶酶体相关细胞器 (LRO)(包括血小板致密颗粒和黑素体)的正常生物发生至关重要。BLOC-1 复合物与 AP-3 复合物一起,对于将膜蛋白货物引导到细胞体形成的囊泡中至关重要,从而促进它们递送到神经突和神经末梢。BLOC-1 复合物与 SNARE 蛋白结合也参与神经突延伸。作为 BORC 复合体的一部分,BLOC1S2 可能有助于溶酶体在细胞外周的运动和定位,与溶酶体的胞质面相关联,并可能招募 ARL8B 将溶酶体与微管正端定向驱动蛋白马达偶联。此外,BLOC1S2 可能在细胞增殖中发挥作用,作为溶酶体相关细胞器复合物 1 (BLOC-1) 和 BLOC-one 相关复合物 (BORC) 生物发生的一部分,与这些复合物内的各种成分相互作用,包括 BLOC1S1、 BLOC1S3、BLOC1S4、BLOC1S5、SNAPIN 和 IFT57。

种属

Human

表达系统

E. coli

标签

N-GST

蛋白编号

Q6QNY1-2 (M1-R99)

基因 ID

282991

蛋白结构
N-term
GST
BLOC1S2 (M1-R99)
Accession # Q6QNY1-2
C-term
蛋白长度

Full Length of Isoform-2

中文名
BLOC1S2 蛋白
同用名
Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; BLOS2; CEAP
氨基酸序列

MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

分子量

Approximately 34 kDa.

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末.

组分

Lyophilized from a 0.22 μm filtered solution of PBS, pH 8.0, 10% trehalose, 0.02% Tween 80.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

BLOC1S2 Protein, Human (N-GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
BLOC1S2 Protein, Human (N-GST)
目录号:
HY-P76171A
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