2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. CD324/E-Cadherin Cadherins
  6. E-Cadherin/Cadherin-1
  7. Cadherin-1/CD324 蛋白, Cynomolgus (HEK293, His)

Cadherin-1/CD324 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700708
产品使用指南

Cadherin-1/CD324 蛋白是骨髓细胞上的钙依赖性受体，与中性粒细胞和单核细胞上的碳水化合物结合。它促进活化的内皮细胞或血小板与白细胞之间的相互作用。它识别唾液酸-Lewis X 作为其配体。通过与 SELPLG 相互作用，它介导早期炎症中白细胞的快速滚动。 Cadherin-1/CD324 蛋白还与 SNX17 相互作用，并根据唾液酸-刘易斯 X 表位和酪氨酸硫酸化促进中性粒细胞粘附和滚动。Cadherin-1/CD324 蛋白, Cynomolgus (HEK293, His) 是重组的 Cadherin-1/CD324 蛋白，由 HEK293 表达，带有 C-His 标签。Cadherin-1/CD324 蛋白, Cynomolgus (HEK293, His) 全长 554 个氨基酸，分子量为 68-78 kDa。

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描述

Cadherin-1/CD324 Protein, a calcium-dependent receptor on myeloid cells, binds to carbohydrates on neutrophils and monocytes. It facilitates interaction between activated endothelial cells or platelets with leukocytes. It recognizes sialyl-Lewis X as its ligand. Through interaction with SELPLG, it mediates rapid leukocyte rolling in early inflammation. Cadherin-1/CD324 Protein also interacts with SNX17 and facilitates neutrophil adhesion and rolling, depending on sialyl-Lewis X epitope and tyrosine sulfation. Cadherin-1/CD324 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Cadherin-1/CD324 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-1/CD324 Protein, Cynomolgus (HEK293, His) is 554 a.a., with molecular weight of 68-78 kDa.
研究背景

P-选择素是一种在骨髓细胞上发现的钙依赖性受体，可与中性粒细胞和单核细胞上存在的碳水化合物结合。它在促进活化的内皮细胞或血小板与白细胞之间的相互作用中起着至关重要的作用。 P-选择素识别的特异性配体是唾液酸-刘易斯 X。通过与 SELPLG 的相互作用，P-选择素在炎症的初始阶段介导白细胞在血管表面的快速滚动。 P-选择素还与 SNX17 相互作用，促进中性粒细胞粘附和白细胞滚动。这种相互作用取决于 SELPLG 和 PODXL2 的唾液酸-Lewis X 表位，以及 SELPLG 上的特异性酪氨酸硫酸化。
种属

Cynomolgus
表达系统

HEK293
标签

C-His
蛋白编号

A0A2K5V299 (D155-P708)
基因 ID

102143513  [NCBI]
蛋白结构
N-term
CADH1 (D155-P708)
Accession # A0A2K5V299
His
C-term
同用名
Cadherin-1; Cadherin1; E-Cadherin; E Cadherin; Epithelial cadherin; CDH1; CD324; Arc-1; CAD1; ECAD; E-CAD; LCAM; UVO; L-CAM;
分子量

68-78 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cadherin-1/CD324 Protein, Cynomolgus (HEK293, His) 相关分类

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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