CD3E-CD3G Heterodimer 蛋白, Rhesus Macaque (HEK293, Fc)

CD3E protein has predicted functions such as SH3 domain binding and protein heterodimerization, and plays a crucial role in nervous system development and cell adhesion. It is involved in T cell activation, cytokine production and signal transduction. CD3E-CD3G Heterodimer Protein, Rhesus Macaque (HEK293, Fc) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD3E-CD3G Heterodimer protein, expressed by HEK293 , with C-hFc labeled tag. CD3E-CD3G Heterodimer Protein, Rhesus Macaque (HEK293, Fc), has molecular weight of ~83 (40 + 43) KDa.

CD3E蛋白预计具有SH3结构域结合活性、相同蛋白结合活性和蛋白异二聚化活性等多种功能，在神经系统发育和细胞粘附的正向调节中发挥着至关重要的作用。它积极参与多个过程的上游，包括T细胞激活的正向调节、细胞因子产生的正向调节以及信号转导的调节。该蛋白质位于多种细胞成分中，包括树突棘、质膜外侧和免疫突触。作为 α-β T 细胞受体复合物的一部分，在结肠和血淋巴系统中观察到其表达。该基因的人类直系同源物 CD3E 对免疫缺陷 18 具有影响，凸显了其在免疫系统功能中的重要性。胸腺和脾脏等组织中存在明显的偏向表达，强调了其在免疫过程中的作用。

Immobilized CD3E&CD3G Heterodimer Protein, at 2μg/mL (100 μL/well) can bind Bispecific BCMA×CD3 T cell-engaging Antibody. The ED₅₀ for this effect is 1.644 ng/mL when detected by Biotinylated Human BCMA.

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  Immobilized CD3E&CD3G Heterodimer Protein, at 2μg/mL (100 μL/well) can bind Bispecific BCMA×CD3 T cell-engaging Antibody .The ED₅₀ for this effect is 1.644 ng/mL when detected by Biotinylated Human BCMA.

Rhesus Macaque

HEK293

C-hFc

XP_014971302 (Q22-D117)&NP_001253854 (Q23-T113)

699467  [NCBI]&705270  [NCBI]

Approximately 83 (40 + 43) kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.