CXCL10 蛋白, Rhesus macaque (His)

CXCL10 protein acts as a chemotactic factor for monocytes and T-lymphocytes, playing a crucial role in their migration in response to inflammatory signals. Through binding to CXCR3, CXCL10 selectively attracts monocytes and T-lymphocytes, positioning it as a key player in immune responses, contributing to the recruitment and activation of these immune cells in various physiological and pathological contexts. CXCL10 Protein, Rhesus macaque (His) is the recombinant Rhesus Macaque-derived CXCL10 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CXCL10 Protein, Rhesus macaque (His) is 77 a.a., with molecular weight of ~11 kDa.

CXCL10 蛋白是单核细胞和 T 淋巴细胞的趋化因子，在协调它们响应炎症信号的迁移中发挥着至关重要的作用。通过与 CXCR3 的结合，CXCL10 建立了一种分子相互作用，促进其化学吸引功能。这种对单核细胞和 T 淋巴细胞的选择性趋化性使 CXCL10 成为免疫反应中的关键参与者，有助于在各种生理和病理环境中招募和激活这些免疫细胞。

Measured in a cytotoxicity assay using HUVEC Human Umbilical Vein Endothelial Cells. The ED₅₀ for this effect is 42.55 pg/mL, corresponding to a specific activity is 2.350×10⁷ units/mg.

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  Measured in a cytotoxicity assay using HUVEC Human Umbilical Vein Endothelial Cells. The ED₅₀ for this effect is 42.55 pg/mL, corresponding to a specific activity is 2.350×10⁷ units/mg.

Rhesus Macaque

E. coli

N-6*His

Q8MIZ1 (I22-P98)

574243  [NCBI]

IPLSRTVRCTCISISNQPVNPRSLEKLEIIPPSQFCPHVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

Approximately 11 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.