CXCL17 蛋白, Human

The CXCL17 protein is a chemokine that attracts monocytes, macrophages, and dendritic cells and plays a role in angiogenesis and potential tumor development. CXCL17 Protein, Human is the recombinant human-derived CXCL17 protein, expressed by E. coli , with tag free.

各种研究表明，CXCL17 蛋白作为一种趋化因子，对单核细胞、巨噬细胞和树突状细胞具有趋化特性。它的参与延伸到血管生成和潜在的肿瘤发展，强调了它在复杂的生理过程中的作用。在胃中，CXCL17 充当抗炎剂，有助于局部免疫调节。此外，有人认为 CXCL17 可能参与针对感染的先天防御，从而扩大了其在免疫反应中的重要性。通过与 CXC 趋化因子受体 GPR35 的相互作用，CXCL17 诱导细胞内钙离子快速且短暂的增加，为其信号传导机制增加了一层特异性。值得注意的是，与 6-Cys CXCL17 相比，CXCL17 对单核细胞和巨噬细胞表现出显着更高的化学引诱效力，强调了其独特的功能特征。

Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 μg/mL, corresponding to a specific activity of >200 IU/mg.

Human

E. coli

Tag Free

Q6UXB2 (S22-L119)

284340  [NCBI]

Full Length of Mature Protein

SSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL

Approximately 12 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm concentrated solution in PBS with 3 % Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.