Enterovirus D68 VP4 蛋白 (sf9, Fc)

Enterovirus D68, a member of Enterovirus genus of the Picornaviridae family, mainly causes respiratory system-related diseases as well as neurological complications in some patients. The capsid of Enterovirus D68 virus is composed of subunit proteins (VP1, VP2, VP3, and VP4). VP1 protein contains multiple epitopes and receptor binding sites and is often used in phylogenetic analysis of viruses. Capsid protein VP4 is released, Capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm. In addition, after binding to the host receptor, the capsid undergoes conformational changes. Enterovirus D68 VP4 Protein (sf9, Fc) is the recombinant Virus-derived Enterovirus D68 VP4 protein, expressed by Sf9 insect cells , with C-Rabbit Fc labeled tag. The total length of Enterovirus D68 VP4 Protein (sf9, Fc) is 69 a.a., with molecular weight of ~32.7 kDa.

肠道病毒 D68 (EV-D68) 是小核糖核酸病毒科肠道病毒属的成员，主要引起呼吸系统相关疾病以及部分患者的神经系统并发症。EV-D68 病毒的衣壳由亚基蛋白 (VP1、VP2、VP3 和 VP4) 组成。VP1、VP2、VP3 位于病毒衣壳表面；VP4 蛋白相对较小，病毒 RNA 位于衣壳内部。VP1 蛋白含有多个表位和受体结合位点，常用于病毒的系统发育分析。VP1 是四种衣壳蛋白中暴露最充分的，在与受体结合中发挥作用。VP1蛋白的 BC 环含有血清型特异性抗原中和位点，可用于区分病毒血清型。VP1 的折叠内部疏水口袋“果冻卷”成脂质分子，即“口袋因子”，在稳定病毒结构方面发挥作用。衣壳蛋白 VP4 被释放，衣壳蛋白 VP1 N 端被外化，它们一起在宿主膜上形成一个孔，病毒基因组通过该孔易位到宿主细胞的细胞质中。另外，与宿主受体结合后，衣壳会发生构象变化^[1]。

Virus

Sf9 insect cells

C-Rabbit Fc

AAR98503 (M1-K69)

37616478  [NCBI]

Approximately 32.7 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.