1. 重组蛋白
  2. CD Antigens Receptor Proteins Fluorescent-labeled Recombinant Proteins
  3. Endothelial cell CD Proteins
  4. U-PAR/CD87
  5. FITC-Labeled uPAR 蛋白, Human (HEK293, His)

FITC-Labeled uPAR 蛋白, Human (HEK293, His)

目录号: HY-P701297
产品使用指南 技术支持

uPAR 蛋白是尿激酶纤溶酶原激活剂的受体,主动定位并促进纤溶酶形成。它介导由 U-PA 激活的独立于蛋白水解的信号传导并经历负反馈调节。FITC-Labeled uPAR 蛋白, Human (HEK293, His) 是重组的 FITC 标记的 uPAR 蛋白,由 HEK293 表达,带有 His 标签。

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SPR 检测服务   重组蛋白定制服务

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

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描述

The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. FITC-Labeled uPAR Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled uPAR protein, expressed by HEK293 , with His labeled tag.

研究背景

uPAR 蛋白作为尿激酶纤溶酶原激活剂的受体,积极参与纤溶酶形成的定位和促进。此外,它还充当 U-PA 诱导的不依赖于蛋白水解的信号转导激活效应的介质。受到 U-PA 的负反馈调节,uPAR 蛋白会裂解成无活性形式。通常作为单体存在,它与多种蛋白质相互作用,包括 MRC2、SRPX2(通过 UPAR/Ly6 结构域)和 FAP (seprase),后者相互作用发生在侵袭伪足膜的细胞表面。此外,uPAR 蛋白与 SORL1 相互作用,特别是通过 N 末端胞外域,并且这种相互作用与 PLAUR 内化的减少有关。值得注意的是,由 PLAUR、PLAU(尿激酶型纤溶酶原激活剂)和 SERPINE1 组成的三元复合物的形成也涉及与 SORL1 的相互作用。

种属

Human

表达系统

HEK293

标签

His

蛋白编号

Q03405 (L23-R303)

基因 ID

5329

蛋白长度

Partial

中文名
FITC标记uPAR 蛋白
同用名
uPAR; PLAUR; CD87; MO3
预测分子量
32.3 kDa
分子量

Approximately 45-60 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FITC-Labeled uPAR Protein, Human (HEK293, His)
目录号:
HY-P701297
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