2. 重组蛋白
  3. CAR-T related Proteins Receptor Proteins Biotinylated Proteins
  4. Folate Receptor alpha (FR-alpha)
  5. FOLR1 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

FOLR1 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

目录号: HY-P78871
产品使用指南 技术支持

FOLR1 蛋白与叶酸和还原叶酸衍生物结合，促进它们进入细胞。它在中性 pH 下保持高亲和力，但在内吞作用下发生构象变化，降低亲和力并在微酸性 pH 下释放叶酸。对于胚胎发育、细胞增殖和肾脏叶酸重吸收至关重要。FOLR1 蛋白, Mouse (Biotinylated, HEK293, His-Avi) 是重组的 FOLR1 蛋白，由 HEK293 表达，带有 C-Avi, C-His 标签。FOLR1 蛋白, Mouse (Biotinylated, HEK293, His-Avi) 全长 208 个氨基酸，分子量为 32-45 kDa。

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SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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100 μg   询价  

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描述

FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FOLR1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 208 a.a., with molecular weight of 32-45 kDa.
研究背景

FOLR1 蛋白与叶酸和还原叶酸衍生物结合，促进 5-甲基四氢叶酸和叶酸类似物输送到细胞中。在中性 pH 条件下，它对叶酸和叶酸类似物表现出高亲和力。内吞作用和暴露于弱酸性 pH 值时，会发生构象变化，导致其对叶酸的亲和力和随后的释放显着降低。这种蛋白质对于正常胚胎发育、细胞增殖和肾脏叶酸重吸收至关重要。
种属

Mouse
表达系统

HEK293
标签

C-Avi;C-His
蛋白编号

P35846 (T25-S232)
基因 ID
中文名
生物素化 FOLR1 蛋白
同用名
FOLR-1; FBP; FOLR
分子量

32-45 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FOLR1 Protein, Mouse (Biotinylated, HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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