HSPA2 蛋白, Human (His)

The HSPA2 protein is a molecular chaperone that protects the proteome, aids in protein folding and transport, activates proteolysis, and regulates protein complex formation. It ensures accurate protein folding and degradation, with substrate affinity related to its nucleotide status. HSPA2 Protein, Human (His) is the recombinant human-derived HSPA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA2 Protein, Human (His) is 638 a.a., .

HSPA2 蛋白是一种分子伴侣，参与对蛋白质组完整性至关重要的多种细胞过程。其功能包括保护蛋白质组免受压力、协助新合成多肽的折叠和运输、激活错误折叠蛋白质的蛋白水解以及协调蛋白质复合物的形成和溶解。作为蛋白质质量控制系统中的关键角色，HSPA2 确保蛋白质的精确折叠、错误折叠对应物的重折叠以及蛋白质的靶向降解。底物蛋白亲和力的调节与其核苷酸结合状态错综复杂地相关。在 ATP 结合状态下，HSPA2 表现出较低的底物蛋白亲和力，但在 ATP 水解为 ADP 后，它会发生构象变化，从而增强其对底物蛋白的亲和力。这一动态过程涉及 ATP 水解和核苷酸交换的重复循环，从而实现连续的底物结合和释放。除了其一般细胞功能外，HSPA2 在精子发生中发挥着至关重要的作用，并且当与 SHCBP1L 相关时，可能有助于雄性生殖细胞减数分裂期间纺锤体完整性的维持。值得注意的是，它与 FKBP6 和 ZNF541 相互作用，突出了它参与各种细胞途径和蛋白质相互作用。此外，HSPA2 形成 CatSper 复合物的一部分，并优先结合 GTP 结合的 RABL2，进一步扩展其功能库。

Human

E. coli

N-6*His

P54652 (S2-D639)

3306

Approximately 72 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, 1 mM DTT, pH 7.5.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.