IP-10/CRG-2/CXCL10 蛋白, Human (HEK293, His-Myc)

IP-10/CRG-2/CXCL10 Protein, a pro-inflammatory cytokine, participates in diverse biological processes, including chemotaxis, immune cell activation, growth regulation, apoptosis, and angiostatic modulation. During viral infections, IP-10 crucially stimulates immune cell activation and migration to infected sites. Mechanistically, its binding to CXCR3 activates G protein-mediated signaling, leading to calcium production and actin reorganization. This cascade recruits Th1 lymphocytes to inflammation sites. In neurons, IP-10 responds to brain injury by activating microglia, crucial for neuronal reorganization. Existing in monomeric, dimeric, and tetrameric forms, IP-10 interacts with CXCR3 through its N-terminus. IP-10/CRG-2/CXCL10 Protein, Human (HEK293, His-Myc) is the recombinant human-derived IP-10/CRG-2/CXCL10 protein, expressed by HEK293, with N-Myc, N-6*His labeled tag. The total length of IP-10/CRG-2/CXCL10 Protein, Human (HEK293, His-Myc) is 77 a.a., with molecular weight of 12.6 kDa.

IP-10 (CXCL10) 是一种促炎细胞因子，参与多种生物过程，包括外周免疫细胞的趋化性、分化和激活、细胞生长调节、细胞凋亡和血管抑制作用的调节。值得注意的是，在病毒感染期间，IP-10 通过刺激免疫细胞激活和迁移到感染部位而发挥关键作用。从机制上讲，CXCL10 与 CXCR3 受体的结合激活 G 蛋白介导的信号传导，导致下游磷脂酶 C 依赖性途径激活、细胞内钙生成增加和肌动蛋白重组。这种级联反应导致活化的 Th1 淋巴细胞募集到炎症部位。CXCL10/CXCR3 轴在神经元中也具有重要意义，它通过激活小胶质细胞（中枢神经系统的常驻巨噬细胞群）来响应脑损伤，并引导它们到达病变部位，这是神经元重组的关键要素。IP-10 以单体、二聚体和四聚体形式存在，并与 CXCR3 相互作用，特别是通过其 N 末端。

Human

HEK293

N-Myc;N-6*His

P02778 (V22-P98)

3627  [NCBI]

VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

12.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.