L1CAM 蛋白, Mouse (HEK293, His)

The L1CAM protein is a neural cell adhesion molecule that plays a key role in cell adhesion dynamics and transmembrane signaling during brain development. It contributes to neuronal migration, axonal growth, fasciculation, and synaptogenesis. L1CAM Protein, Mouse (HEK293, His) is the recombinant mouse-derived L1CAM protein, expressed by HEK293 , with C-His labeled tag. The total length of L1CAM Protein, Mouse (HEK293, His) is 1104 a.a., with molecular weight of 160-180 kDa.

L1CAM 蛋白是一种神经细胞粘附分子，在细胞粘附动力学和酪氨酸激酶受体跨膜信号的产生中发挥着关键作用。它的参与在大脑发育过程中尤其重要，它有助于多个过程，包括神经元迁移、轴突生长和束化以及突触发生。在成熟的大脑中，L1CAM 继续对神经元结构和功能的动态发挥影响，参与突触可塑性。此外，L1CAM 与 SHTN1 相互作用，相互作用发生在轴突生长锥中。此外，它与 BSG 的亚型 2 结合，强调其在影响神经发育和功能各个方面的分子相互作用中的多功能性。

Mouse

HEK293

C-His

P11627 (I20-E1123)

16728  [NCBI]

160-180 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.