1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokines
  5. LAG-1/CCL4L1 蛋白, Human

LAG-1/CCL4L1 蛋白作为趋化因子,可以在表达 CCR5CCR1 的细胞中诱导趋化性,表明其在细胞迁移(趋化性)中的作用。此外,它还证明了抑制 HIV 复制的能力,特别是在表达 CCR5 的外周血单核细胞中,这表明它对抗病毒防御机制具有潜在影响。LAG-1/CCL4L1 蛋白, Human 是重组的 LAG-1/CCL4L1 蛋白,由 E. coli 表达,不带标签。

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描述

LAG-1/CCL4L1 protein acts as a chemokine and can induce chemotaxis in cells expressing CCR5 or CCR1, indicating its role in cell migration (chemotaxis). Furthermore, it demonstrated the ability to inhibit HIV replication, particularly in CCR5-expressing peripheral blood mononuclear cells, suggesting a potential impact on antiviral defense mechanisms. LAG-1/CCL4L1 Protein, Human is the recombinant human-derived LAG-1/CCL4L1 protein, expressed by E. coli , with tag free.

研究背景

LAG-1 (CCL4L1) 是一种趋化因子,能够在表达 CCR5CCR1 的细胞中诱导趋化性。值得注意的是,LAG-1 对表达 CCR5 的外周血单核细胞中的 HIV 复制具有抑制作用,突显了其在针对病毒感染的免疫防御机制中的潜在作用。该蛋白通过与 CCR5 相互作用来实现其趋化作用,强调了其在调节细胞反应方面的特异性。LAG-1 影响趋化性和抑制 HIV 复制的能力表明其在协调免疫反应中的重要性以及对抗病毒感染的潜在治疗意义(参考:未提供具体参考)。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q8NHW4-1 (A24-N92)

基因 ID

388372

蛋白结构
N-term
LAG-1 (A24-N92)
Accession # Q8NHW4
C-term
蛋白长度

Full Length of Mature Protein

中文名
LAG-1 蛋白/CC趋化因子配体 4L1 蛋白
同用名
CCL4L1; chemokine (C-C motif) ligand 4-like 1; CCL4L, chemokine (C C motif) ligand 4 like, SCYA4L, small inducible cytokine A4 like; C-C motif chemokine 4-like; AT744.2; LAG 1; MIP-1-beta; macrophage inflammatory protein-1b2; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; monocyte adherence-induced protein 5-alpha; LAG1; CCL4L; LAG-1; SCYA4L;
氨基酸序列

APMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADPSESWVQEYVYDLELN

预测分子量
7.8 kDa
分子量

Approximately 15 kDa, based on SDS-PAGE under reducing conditions.

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

LAG-1/CCL4L1 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
LAG-1/CCL4L1 Protein, Human
目录号:
HY-P701233
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