MCEMP1 蛋白, Mouse (HEK293, Fc)

MCEMP1, a type II transmembrane protein, is a lung-specific surface protein and functions as an adaptor for KIT, which promotes SCF-mediated mast cell proliferation. MCEMP1 elicits intracellular signaling through its cytoplasmic immunoreceptor tyrosine-based activation motif and forms a complex with KIT to enhance its autophosphorylation and activation. MCEMP1 regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner. MCEMP1 acts as a critical factor in allergic and inflammatory lung diseases^[1][2]. MCEMP1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived MCEMP1 protein, expressed by HEK293 , with N-hFc labeled tag.

MCEMP1 缺陷会损害 SCF 诱导的体外腹膜肥大细胞增殖和体内肺肥大细胞扩张。Mcemp1 缺陷小鼠在慢性哮喘小鼠模型中表现出气道炎症和肺损伤减轻。KIT 的 JM 和 KD1 区域的缺失导致与 MCEMP1 的结合丧失，表明 MCEMP1 可能与 KIT 的 JM 或 KD1 结构域相互作用，干扰其自抑制结构，并使 KIT 的激酶结构域保持活性形式。人 MCEMP1 与小鼠 MCEMP1 直系同源物具有 44% 的氨基酸序列同一性。MCEMP1 是在慢性哮喘发展过程中介导免疫反应和气道炎症的关键因素^[1][2]。

Mouse

HEK293

N-hFc

Q9D8U6 (K92-T183)

69189  [NCBI]

Extracellular Domain

40-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.