2. 重组蛋白
  3. Cytokines and Growth Factors
  4. MIF 蛋白, Human (HEK293, hFc)

MIF 蛋白, Human (HEK293, hFc)

目录号: HY-P700425
产品使用指南

MIF 蛋白是一种促炎细胞因子，对针对细菌病原体的先天免疫反应至关重要。它在炎症部位的存在表明在调节巨噬细胞功能以促进宿主防御方面发挥作用。MIF 抵消糖皮质激素的抗炎作用，在体外表现出互变异构酶活性。MIF 蛋白, Human (HEK293, hFc) 是重组的 MIF 蛋白，由 HEK293 表达，带有 C-hFc 标签。MIF 蛋白, Human (HEK293, hFc) 全长 114 个氨基酸，分子量为 41.3 kDa。

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描述

The MIF protein is a pro-inflammatory cytokine that is critical for the innate immune response against bacterial pathogens. Its presence at sites of inflammation suggests a role in modulating macrophage function to promote host defense. MIF counteracts the anti-inflammatory effects of glucocorticoids. Although MIF exhibits tautomerase activity in vitro, its physiological substrates remain unknown, and the relevance of this activity to its cytokine function is unclear. MIF Protein, Human (HEK293, hFc) is the recombinant human-derived MIF protein, expressed by HEK293, with C-hFc labeled tag. The total length of MIF Protein, Human (HEK293, hFc) is 114 a.a., with molecular weight of 41.3 kDa.
研究背景

MIF 蛋白是一种促炎细胞因子，在针对细菌病原体的先天免疫反应中发挥着至关重要的作用。它在炎症部位的表达表明它参与调节宿主防御中的巨噬细胞功能。MIF 抵消糖皮质激素的抗炎作用。尽管 MIF 在体外具有苯丙酮酸互变异构酶和多巴色素互变异构酶活性，但 MIF 的生理底物仍不清楚。目前尚不清楚互变异构酶活性是否与其细胞因子活性相关。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

P14174 (P2-A115)
基因 ID
蛋白结构
N-term
MIF (P2-A115)
Accession # P14174
hFc
C-term
同用名
MIF; macrophage migration inhibitory factor; GIF; GLIF; MMIF; phenylpyruvate tautomerase; glycosylation-inhibiting factor; EC 5.3.2.1; Glycosylation-inhibiting factor; Phenylpyruvate tautomerase
氨基酸序列

PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

分子量

41.3 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

MIF Protein, Human (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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