MMP-19 蛋白, Human

MMP-19 proteins act as endopeptidases that degrade multiple components of the extracellular matrix, including aggrecan and cartilage oligomeric matrix protein (comp), during critical developmental processes, hemostasis, and pathological conditions such as arthritis. ) plays a key role. In addition to participating in matrix remodeling, MMP-19 may also contribute to neovascularization, or angiogenesis. MMP-19 Protein, Human is the recombinant human-derived MMP-19 protein, expressed by E. coli , with tag free.

MMP-19（基质金属蛋白酶-19）是一种肽链内切酶，在降解细胞外基质的各种成分（包括聚集蛋白聚糖和软骨寡聚基质蛋白 (COMP)）方面发挥着至关重要的作用，特别是在发育、止血和关节炎等病理状况期间。此外，MMP-19 可能有助于新血管形成或血管生成，表明其参与与新血管形成相关的过程。该酶表现出广泛的底物特异性，可水解关键的细胞外基质蛋白，例如 IV 型胶原、层粘连蛋白、巢蛋白、nascin-C 同种型、纤连蛋白和 I 型明胶。MMP-19 裂解不同底物的能力强调了其在组织重塑和修复中的重要性，以及其对以异常细胞外基质周转为特征的病理状况的潜在影响。（

Immobilized Human MMP-19 Protein at 2 μg/mL (100 μL/well) can bind Anti-MMP-19 antibody. The ED₅₀ for this effect is 99.49 ng/mL.

Human

E. coli

Tag Free

Q99542-1 (L101-G256)

4327

Partial

Approximately 18 kDa, based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of 0.1% TFA, 30% Acetonitrile, pH 2.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.