PADI2 蛋白, Cynomolgus (sf9, His)

The PADI2 protein plays a key role in cellular processes by catalyzing the deimination of protein arginine residues. This enzymatic activity, called citrullination, involves the conversion of arginine to citrulline, affecting the structure and function of the target protein. PADI2 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived PADI2 protein, expressed by sf9 insect cells , with N-His labeled tag.

肽基精氨酸脱亚胺酶 2 (PADI2) 是一种催化蛋白质中精氨酸残基脱亚胺的酶。这种翻译后修饰也称为瓜氨酸化，涉及通过去除氨基将精氨酸转化为瓜氨酸。瓜氨酸化在各种生物过程中发挥着至关重要的作用，包括基因表达的调节、免疫反应和某些蛋白质结构的形成。PADI2 介导的脱亚胺作用与类风湿性关节炎等自身免疫性疾病的发病机制有关，其中瓜氨酸蛋白通常是免疫系统的目标。参考文献简洁地概述了 PADI2 在将瓜氨酸修饰引入精氨酸残基方面的催化功能，强调了其在调节蛋白质结构和功能中的作用。

Cynomolgus

sf9 insect cells

N-His

A0A2K5TST4 (M1-P665)

/

Full Length

MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSERVRVEVMRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEMVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCDLKVCFQYINRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFEPVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDKDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP

Approximately 75-85 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reduced SDS-PAGE.

<1 EU/μg, determined by LAL method.