RGMB 蛋白, Mouse (HEK293, His)

RGMB, a member of the RGM family, shapes the developing nervous system as a BMP coreceptor. It enhances BMP signaling and modulates neuronal adhesion. RGMB forms homooligomers and interacts with DRGX, BMP2, BMP4, ACVR1, BMPR1A, BMPR1B, and ACVR2B. It also forms a functional complex with NEO1/neogenin, activating downstream signaling via RhoA. RGMB Protein, Mouse (HEK293, His) is the recombinant mouse-derived RGMB protein, expressed by HEK293 , with C-10*His labeled tag.

排斥引导分子 B (RGMB) 是排斥引导分子 (RGM) 家族的一员，在塑造神经系统发育过程中发挥着关键作用。作为骨形态发生蛋白 (BMP) 辅助受体，RGMB 增强 BMP 信号传导并有助于调节神经元粘附。在潜在抑制神经突生长的同时，RGMB 形成同源寡聚物并与 DRGX、BMP2、BMP4 以及 BMP I 型受体（ACVR1、BMPR1A、BMPR1B）和 BMP II 型受体（ACVR2B）相互作用。值得注意的是，RGMB 与其受体 NEO1/neogenin 形成功能复合物，以 2:2 化学计量排列为异四聚体，其中 RGMB 分子充当主食，将两个 NEO1 受体结合在一起，而不会相互接合。这种安排导致通过 RhoA 激活下游信号传导。

Mouse

HEK293

C-10*His

Q7TQ33/NP_848730.2 (G49-C415)

68799  [NCBI]

Full Length of Rgmb

GDCQQPTQCRIQKCTTDFVALTAHLNSAADGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYHSHGGVREHGGGDQRPPNYLFCGLFGDPHLRTFKDHFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKVTIIFKAQHECTDQKVYQAVTDDLPAAFVDGTTSGGDGDVKSLHIVEKESGRYVEMHARYIGTTVFVRQLGRYLTLAIRMPEDLAMSYEESQDLQLCVNGCPMSECIDDGQGQVSAILGHSLPHTTSVQAWPGYTLETASTQCHEKMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWHIFPSSC

Approximately 40.2 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.