RGS17 蛋白, Human (GST)

RGS17 protein centrally regulates G protein-coupled receptor signaling, inhibiting signal transduction by enhancing G protein alpha subunit GTPase activity. It selectively binds to GNAZ and GNAI2 subunits, accelerating GTPase activity and modulating signaling. Additionally, RGS17 negatively regulates mu-opioid receptor-mediated G-protein activation, forming complexes with receptors and Gαz/i2 subunits. Molecular interactions include binding to OPRM1 and interacting with HINT1, highlighting its role in a complex regulatory network for diverse G protein-dependent signaling pathways. RGS17 Protein, Human (GST) is the recombinant human-derived RGS17 protein, expressed by E. coli, with N-GST labeled tag. The total length of RGS17 Protein, Human (GST) is 210 a.a., with molecular weight of 51.4 kDa.

RGS17 蛋白在 G 蛋白偶联受体信号级联的调节中发挥着关键作用，包括由毒蕈碱乙酰胆碱受体 CHRM2 和多巴胺受体 DRD2 介导的信号级联。其调节功能包括通过增强 G 蛋白 α 亚基的 GTPase 活性来抑制信号转导，从而促进其转变为无活性的 GDP 结合形式。RGS17 选择性结合 GNAZ 和 GNAI2 亚基，加速其 GTP 酶活性并调节其信号传导活性。此外，RGS17 负向调节 mu-阿片受体介导的 G 蛋白激活。该蛋白与 GNAI1 和 GNAQ 相互作用，并与 mu-阿片受体和 G(α)z/i2 亚基形成复合物，有助于 mu-阿片受体脱敏。进一步的分子相互作用包括与 OPRM1 结合以及与 HINT1 相互作用，强调了 RGS17 参与调节多种 G 蛋白依赖性信号通路的复杂调控网络。

Human

E. coli

N-GST

Q9UGC6 (M1-S210)

26575  [NCBI]

MRKRQQSQNEGTPAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGENAGRPTHTTKMESIQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSFVESTAGSSSES

51.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.