Sap130 蛋白, Mouse (His)

Sap130 Protein, a transcriptional repressor, participates in mSin3A corepressor complex assembly or enzymatic activity. It's a component of the complex, including SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1, and HDAC2. Sap130 also interacts with CLEC4E, especially when released by dead or dying cells. Sap130 Protein, Mouse (His) is the recombinant mouse-derived Sap130 protein, expressed by E. coli, with N-6*His labeled tag. The total length of Sap130 Protein, Mouse (His) is 213 a.a., with molecular weight of ~34 kDa.

Sap130 蛋白作为转录阻遏蛋白，可能在 mSin3A 辅阻遏物复合物的组装和/或酶活性中发挥作用，或介导该复合物与其他调节复合物之间的相互作用。它是 mSin3A 辅抑制复合物的组成部分，由 SIN3A、SAP130、SUDS3/SAP45、ARID4B/SAP180、HDAC1 和 HDAC2 组成。此外，Sap130 与 CLEC4E 相互作用，特别是当死亡或垂死细胞释放时。

Mouse

E. coli

N-6*His

Q8BIH0 (P845-V1057)

269003  [NCBI]

PRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV

Approximately 34 kDa.The reducing (R) protein migrat es as 34 kDa in SDS-PAGE may be due to molecular structure of protein.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trchalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.