TIM-4/TIMD-4 蛋白, Mouse (HEK293, His)

TIM-4/TIMD-4 Protein, a phosphatidylserine receptor, regulates the immune response through diverse roles. It participates in apoptotic cell phagocytosis and modulates T-cell function. In T-cell activation, it induces cell cycle arrest in naive T-cells while enhancing activated T-cell proliferation through AKT1 and ERK1/2 phosphorylation. TIM-4/TIMD-4 plays a pivotal role in efferocytosis, directly binding to apoptotic cell phosphatidylserine for engulfment. Additionally, it promotes autophagy by suppressing NLRP3 inflammasome activity via the STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism. The protein's homodimer formation contributes to its multifaceted immune regulation. TIM-4/TIMD-4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TIM-4/TIMD-4 protein, expressed by HEK293, with C-His labeled tag. The total length of TIM-4/TIMD-4 Protein, Mouse (HEK293, His) is 257 a.a., with molecular weight of 60-70 kDa.

TIM-4/TIMD-4 蛋白作为磷脂酰丝氨酸受体，在免疫反应中发挥多种作用，参与凋亡细胞的吞噬作用和 T 细胞功能的调节。它对 T 细胞激活的参与是双模式的，因为它通过诱导细胞周期停滞来减少初始 T 细胞的激活，同时通过激活 AKT1 和 ERK1/2 磷酸化以及随后的信号通路来增强激活 T 细胞的增殖。此外，TIM-4/TIMD-4 通过直接与凋亡细胞上的磷脂酰丝氨酸结合，从而促进其被吞噬细胞吞噬，从而在胞吞作用（凋亡细胞的吞噬过程）中发挥关键作用。这种功能是独特的，因为其他吞噬受体（如 MERTK）在识别和介导凋亡细胞的摄取方面更有效。此外，TIM-4/TIMD-4 通过在磷脂酰丝氨酸依赖性机制中激活 STK11/PRKAA1 通路来抑制 NLRP3 炎性体活性，从而促进自噬过程。该蛋白质形成同二聚体，在免疫调节中发挥多方面的作用。

Mouse

HEK293

C-His

Q6U7R4/NP_848874.3 (A23-T279)

276891  [NCBI]

60-70 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.