TMEFF1/Tomoregulin-1 蛋白, Human (HEK293, Fc)

TMEFF1/Tomoregulin-1 protein may inhibit NODAL and BMP signaling in neural patterning, suggesting a regulatory role in neural development. It has been proposed as a tumor suppressor in brain cancer, emphasizing its importance in mitigating abnormal cell growth. TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is 291 a.a., with molecular weight of ~65 kDa.

TMEFF1/Tomoregulin-1 蛋白可能在神经模式形成过程中抑制 NODAL 和 BMP 信号传导，表明其在控制神经发育的调节过程中的作用。此外，TMEFF1 被认为在脑癌中发挥肿瘤抑制因子的作用，强调了其在减轻神经组织异常细胞生长方面的潜在意义。此外，该蛋白可能与 ST14 相互作用，这意味着分子关联可能有助于其调节和信号传导功能。TMEFF1 的多方面作用凸显了它在正常发育过程中的重要性以及它在脑癌等病理状况中的潜在参与。

Human

HEK293

C-hFc

Q8IYR6 (S40-V330)

100526694  [NCBI]

SNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV

Approximately 65 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.