TNF RII/TNFRSF1B 蛋白, Human (Biotinylated, HEK293, His)

The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-His labeled tag.

TNFRII 蛋白作为受体，对 TNFSF2/TNF-α 具有高亲和力，对同源三聚体 TNFSF1/淋巴毒素-α 的亲和力低约 5 倍。TRAF1/TRAF2 复合物将细胞凋亡抑制因子 BIRC2 和 BIRC3 募集至 TNFRSF1B/TNFR2，从而调节细胞凋亡途径。该受体在介导 TNF-α 诱导的大部分代谢作用中发挥着关键作用。值得注意的是，其亚型 2 表现出阻断 TNF-α 诱导的细胞凋亡的能力，表明在拮抗 TNF-α 的生物活性中具有调节作用。此外，TNFRII 与 TRAF2 结合，突显其参与下游信号级联反应。此外，与 BMX 和 XPNPEP3 激活形式的相互作用进一步增加了其分子关联的复杂性。

Human

HEK293

C-His

P20333-1 (L23-D257)

7133  [NCBI]

Extracellular Domain

Approximately 40-60 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.