VEGF120 蛋白, Mouse (Biotinylated, His-Avi)

VEGF-A Protein is a key member of the VEGF family of cytokines. VEGF-A participates in angiogenesis, vasculogenesis, and endothelial cell growth, inducing endothelial cell proliferation, promoting cell migration, inhibiting cell apoptosis, and inducing vascular permeability. VEGF-A stimulates endothelial cell mitogenesis and cell migration. VEGF120 Protein, Mouse (Biotinylated, His-Avi) is the recombinant mouse-derived VEGF120 protein, expressed by E. coli , with N-His, N-Avi labeled tag. The total length of VEGF120 Protein, Mouse (Biotinylated, His-Avi) is 120 a.a., with molecular weight of 22-24 kDa.

VEGF-A 是 VEGF 细胞因子家族的重要成员，其他成员还有 VEGF-B、-C、-D 和 PGF。VEGF-A 参与血管生成、血管发生和内皮细胞生长，诱导内皮细胞增殖、促进细胞迁移、抑制细胞凋亡、诱导血管通透性。VEGF-A 与 FLT1/VEGFR1、KDR/VEGFR2 和 DEAR/FBXW7-AS1 受体、硫酸乙酰肝素和肝素结合。VEGF-A 还与 NRP1 结合，启动运动神经元轴突引导和细胞体迁移所需的信号通路，包括胚胎发育过程中面部运动神经元从菱形 4 到菱形 6 的尾部迁移。VEGF-A 刺激内皮细胞有丝分裂和细胞迁移。VEGF-A 也是一种血管扩张剂并增加微血管通透性^{[1][2][3][4][5]}。

Mouse

E. coli

N-His;N-Avi

Q00731-3 (A27-R146)

22339  [NCBI]

22-24 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.