WISP1/CCN4 蛋白, Mouse (HEK293, His)

WISP1/CCN4 Protein, a member of the CCN family, is involved in cellular processes such as cell proliferation, migration, and differentiation. It is implicated in various diseases, including cancer and fibrosis. The potential therapeutic targeting of WISP1/CCN4 Protein and its role in disease pathogenesis make it a subject of interest in biomedical research. WISP1/CCN4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived WISP1/CCN4 protein, expressed by HEK293 , with C-His labeled tag. The total length of WISP1/CCN4 Protein, Mouse (HEK293, His) is 345 a.a., with molecular weight of 55-75 kDa.

WISP1/CCN4 蛋白作为 Wnt/Frizzled 信号通路的下游调节因子，参与细胞存活。它显示出对皮肤和黑色素瘤成纤维细胞的粘附，可能是通过与核心蛋白聚糖和双聚糖等蛋白聚糖结合而实现的。此外，WISP1/CCN4 蛋白已被证明具有抑制体内肿瘤生长的能力。

Measured by its ability to inhibit the cell growth of DU145 human prostate cancer cells. The ED₅₀ for this effect is 0.9133 µg/mL, corresponding to a specific activity is 1094.930 U/mg.

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  Measured by its ability to inhibit the cell growth of DU145 human prostate cancer cells. The ED₅₀ for this effect is 0.9133 µg/mL, corresponding to a specific activity is 1094.930 U/mg.

Mouse

HEK293

C-His

O54775 (T23-N367)

22402  [NCBI]

TALSPTPTTMTFTPAPLEETTTRPEFCKWPCECPQSPPRCPLGVSLITDGCECCKICAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYTNGESFQPNCRYNCTCIDGTVGCTPLCLSPRPPRLWCRQPRHVRVPGQCCEQWVCDDDARRPRQTALLDTRAFAASGAVEQRYENCIAYTSPWSPCSTTCGLGISTRISNVNARCWPEQESRLCNLRPCDVDIQLHIKAGKKCLAVYQPEEATNFTLAGCVSTRTYRPKYCGVCTDNRCCIPYKSKTISVDFQCPEGPGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFEEIAN

55-75 kDa

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  Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.