2. Apoptosis Immunology/Inflammation
  3. RIP kinase NOD-like Receptor (NLR) TNF Receptor
  4. RIPK2-IN-7

RIPK2-IN-7 (Compound 10w) 是一种具有口服活性的选择性 RIPK2 抑制剂 (IC50: 0.6 nM)。RIPK2-IN-7 主要通过抑制 RIPK2 激酶活性，阻断核苷酸结合寡聚化结构域 (NOD) 信号通路，减少炎症因子 (如 TNFα) 的产生。RIPK2-IN-7 可用于炎症性肠病 (IBD) 的研究。

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RIPK2-IN-7 Chemical Structure

RIPK2-IN-7 Chemical Structure

CAS No. : 2789711-40-4

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RIPK2-IN-7 相关抗体

Top Publications Citing Use of Products

查看 RIP kinase 亚型特异性产品:

查看所有亚型
RIPK1 RIPK2 RIPK3

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RIPK2-IN-7 (Compound 10w) is an orally active, selective RIPK2 inhibitor (IC50: 0.6 nM). RIPK2-IN-7 inhibits RIPK2 kinase activity, blocks the nucleotide-binding oligomerization domain (NOD) signaling pathway, and reduces the production of inflammatory factors (such as TNFα). RIPK2-IN-7 can be used in the study of inflammatory bowel disease (IBD)[1].

IC50 & Target[1]

RIPK2

0.6 nM (IC50)

分子量

339.41

Formula

C19H22FN5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RIPK2-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK2-IN-72789711-40-4RIP kinaseNOD-like Receptor (NLR)TNF ReceptorReceptor-interacting protein kinasesRIPKTumor Necrosis Factor ReceptorTNFRIBDinhibitionproteinRIPK2Raw264.7 cellsBMDM cellsBalb/C miceInhibitorinhibitorinhibit

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