2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. RNA binder 1

RNA binder 1 (Compound 4b) 是一种可透过血脑屏障的 RNA 结合剂。RNA binder 1 能够选择性结合 C9orf72 基因的 G4C2 重复序列 RNA 的 G-四链体结构。RNA binder 1 显著降低肌萎缩侧索硬化症 (ALS) 患者衍生细胞中由 G4C2 重复序列产生的毒性多肽 poly(GA) 和 poly(GP) 的水平。RNA binder 1 对反义多肽 poly(PR) 无显著影响，表现出对正义 RNA 的选择性。RNA binder 1可用于 ALS 和额颞叶痴呆 (FTD) 的研究。

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RNA binder 1 Chemical Structure

RNA binder 1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

RNA binder 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD)[1].

分子量

488.59

Formula

C22H20N10S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RNA binder 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RNA binder 1RNA binder1RNA binder-1DNA/RNA SynthesisC9orf72 geneALSRNABBBHEK293T cellssmNPC cellsNS34 cellsInhibitorinhibitorinhibit

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目录号：
HY-172902
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