2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2 nsp14-IN-2

SARS-CoV-2 nsp14-IN-2 是一种有效的SARS-CoV-2 Nsp14 甲基转移酶 (SARS-CoV-2 Nsp14 methyltransferase) 抑制剂，IC50 值为 0.093 µM。SARS-CoV-2 nsp14-IN-2 显示出抗病毒活性 SARS-CoV-2 nsp14-IN-2 显示血浆和肝脏 S9 稳定性。SARS-CoV-2 nsp14-IN-2 具有研究 COVID-19 的潜力。

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SARS-CoV-2 nsp14-IN-2 Chemical Structure

SARS-CoV-2 nsp14-IN-2 Chemical Structure

CAS No. : 2816165-16-7

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SARS-CoV-2 nsp14-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2 nsp14-IN-2 is a potent SARS-CoV-2 Nsp14 methyltransferase inhibitor with an IC50 value of 0.093 µM. SARS-CoV-2 nsp14-IN-2 shows antiviral activity. SARS-CoV-2 nsp14-IN-2 shows plasma and liver S9 stability. SARS-CoV-2 nsp14-IN-2 has the potential for the research of COVID-19[1].

IC50 & Target

IC50: 0.093 µM (SARS-CoV-2 Nsp14 methyltransferase)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 CC50
> 100 μM
Compound: 10
Cytotoxicity against human A549 cells overexpressing ACE2 and TMPRSS2 incubated for 48 hrs by MTS assay
Cytotoxicity against human A549 cells overexpressing ACE2 and TMPRSS2 incubated for 48 hrs by MTS assay
[PMID: 36097498]
体外研究
(In Vitro)

SARS-CoV-2 nsp14-IN-2 (compound 10) (0-100 µM) shows antiviral activity with an EC50 value of 0.72 µM and CC50 value of >100 µM[1].
SARS-CoV-2 nsp14-IN-2 (24 h) shows plasma stability with t1/2s of >24, >24 h for human and mouse, respectively[1].
SARS-CoV-2 nsp14-IN-2 (45 min) shows liver S9 stability with t1/2 values of 842 min and >45 min in Phase I and phase II in human liver, respectively; and t1/2 values of 28.9 min and >45 min in Phase I and phase II in mouse liver, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 nsp14-IN-2 相关抗体:
分子量

455.49

Formula

C21H21N5O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV-2 nsp14-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 nsp14-IN-22816165-16-7SARS-CoVSARS coronavirusantiviral activityplasma stabilityliver S9 stabilityCOVID-19Inhibitorinhibitorinhibit

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