2. Anti-infection Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Apoptosis
  3. Antibiotic ADC Cytotoxin DNA Alkylator/Crosslinker Apoptosis
  4. Seco-Duocarmycin SA

Seco-Duocarmycin SA 是一种 DNA 烷化剂 (DNA alkylator)。Seco-Duocarmycin SA 是一种抗肿瘤抗生素 (IC50 = 10 pM)。Seco-Duocarmycin SA 可诱导凋亡细胞死亡 (apoptosis)，且呈浓度依赖性增加。Seco-Duocarmycin SA 可导致细胞周期显著停滞于 S 期和 G2/M 期。Seco-Duocarmycin SA 可作为抗体-药物偶联物的 ADC 细胞毒素。

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Seco-Duocarmycin SA Chemical Structure

Seco-Duocarmycin SA Chemical Structure

CAS No. : 144667-38-9

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Other Forms of Seco-Duocarmycin SA:

Seco-Duocarmycin SA 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates[1][2][3].

IC50 & Target[1]

Duocarmycins

 

DNA alkylator

 

体外研究
(In Vitro)

Seco-Duocarmycin SA (Compound seco-DSA) (0-0.05 nM) 在多形性胶质母细胞瘤 (GBM) 细胞系 LN18 (IC50 = 0.005 nM) 和 T98G (IC50 = 0.008 nM) 中表现出显著的抑制作用[2]。
Seco-Duocarmycin SA (0-1 nM，72 小时) 可抑制 LN18 (IC50 = 0.12 nM) 和 T98G (IC50 = 0.28 nM) 细胞系的增殖。[2]。
Seco-Duocarmycin SA (0-0.28 nM, 0-24 小时) 在 8 小时内达到最大疗效[2]。
Seco-Duocarmycin SA (0.1-0.28 nM，24-72 小时) 导致 T98G 细胞中的 G1 期显著减少，同时 S 和 G2/M 期增加，以及 LN18 和 T98G 细胞中的 G2/M 期显著增加[2]。
Seco-Duocarmycin SA (0.1-0.28 nM, 24 小时) 抑制 LN18 和 T98G 细胞的迁移[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Seco-Duocarmycin SA 相关抗体:

Cell Viability Assay[2]

Cell Line: LN18 and T98G
Concentration: 0, 0.2, 0.4, 0.6, 0.8, 1 nM
Incubation Time: 72 h
Result: Inhibited cell viability in both LN18 (IC50 = 0.21 nM) and T98G (IC50 = 0.25 nM) cell lines.
分子量

513.93

Formula

C25H24ClN3O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Seco-Duocarmycin SA 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seco-Duocarmycin SA144667-38-9AntibioticADC CytotoxinDNA Alkylator/CrosslinkerApoptosisADC PayloadInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-129356
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