1. Apoptosis
  2. TNF Receptor
  3. Selicrelumab

Selicrelumab  (Synonyms: 塞鲁单抗)

目录号: HY-P99046 纯度: 97.64%
COA 技术支持

Selicrelumab 是一种 CD40 抗体激动剂,可诱导肿瘤微环境的变化。Selicrelumab 可用于胰腺癌的研究和肿瘤新辅助疗法研究。

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CAS No. : 1622140-49-1

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规格 价格 是否有货 数量
1 mg ¥3000
In-stock
5 mg ¥7800
In-stock
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50 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Selicrelumab is an agonist CD40 antibody, induces changes in the tumor microenvironment. Selicrelumab can be used for the research of pancreatic cance and neoadjuvant study[1].

同型

Human IgG2 kappa

推荐同型对照抗体
种属

Human

体外研究
(In Vitro)

Selicrelumab (10 µg/mL, 2-3 days) 可在慢性淋巴细胞白血病 (CLL) 细胞上激活 CD40 受体,上调原代 CLL 细胞中的共刺激分子 (CD86)、细胞因子 (TNF-α) 和死亡受体 (CD95) 表达[2]
Selicrelumab (10 µg/mL, 2 days) 可促进抗凋亡蛋白 MCL-1 的表达,诱导 CLL 细胞对 Venetoclax (HY-15531) 的耐药性[2]
Selicrelumab (10 µg/mL, 2 days) 通过溶酶体介导的机制增强 CLL 细胞对 GA101 (HY-P9910) 诱导的细胞死亡的敏感性[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: primary CLL cell
Concentration: 10 µg/mL
Incubation Time: 2 days
Result: Upregulated the expression of Mcl-1.
Clinical Trial
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

146.2 kDa

同用名

塞鲁单抗

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

塞鲁单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG2 kappa
纯度 & 产品资料

纯度: 97.64%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Selicrelumab
目录号:
HY-P99046
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