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  4. Serpin B9-IN-1

Serpin B9-IN-1 (BTCA) 是特异性靶向 Serpin B9 (SB9) 的抑制剂；而 SB9 是颗粒酶 B (GrB) 的天然抑制剂，但可能促进肺癌细胞转移进骨髓。SB9 过表达的癌细胞通过结合 GrB，通过免疫细胞依赖的方式促进增殖和转移。Serpin B9-IN-1 抑制 SB9 显著抑制尾动脉 (CA) 小鼠模型中的肺癌骨转移的免疫治疗 (LCBM)。

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Serpin B9-IN-1 Chemical Structure

Serpin B9-IN-1 Chemical Structure

CAS No. : 154235-77-5

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1 g ￥127
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5 g ￥400
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Serpin B9-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1].

IC50 & Target

IC50: Serpin B9
体内研究
(In Vivo)

Serpin B9-IN-1 (BTCA) 在多种肿瘤转移模型中抑制骨转移 (BM)。Serpin B9-IN-1 (50 mg/kg/d; ip; 14 d) 在尾动脉注射 (CA) 有 LLC1-BM3 的小鼠骨转移模型中有效降低了转移癌细胞的存活率和转移比例[1]。
Serpin B9-IN-1 (300 μg/d; ip; 14 d) 有效延迟了 LLC1-BM3 细胞组发生骨转移（BM）的平均时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LLC1-BM3 Bone Metastatic Mouse Model by CA injections[1]
Dosage: 50 mg/kg
Administration: ip; followed after cancer cell injection, injection daily for 14 days
Result: Reduced the survival rate and metastasis proportion of metastatic cancer cells
Animal Model: LLC1-BM3-sr-ctrl Model in Mouse[1]
Dosage: 300 μg
Administration: ip; once daily for 14 days
Result: Delayed the mean time to occurrence of bone metastasis (BM), and lowered the burden of BM in LLC1-BM3-shSB9 cells group.
分子量

163.13

Formula

C8H5NO3
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥97.0%

COA (263 KB) HNMR (224 KB)

产品使用指南 (1538 KB)
参考文献

Serpin B9-IN-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Serpin B9-IN-1154235-77-5BTCAOthersImmunotherapy for bone metastasis of lung cancerLCBMInhibitorinhibitorinhibit

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目录号：
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