2. Anti-infection
  3. Virus Protease
  4. SGC-NSP2hel-1

SGC-NSP2hel-1  (Synonyms: RA-0188293)

目录号: HY-176268
产品使用指南 技术支持

SGC-NSP2hel-1 是一种强效、特异性且口服有效的 nsP2 解旋酶抑制剂，CC50 大于 250 µM，选择性指数大于 4000。SGC-NSP2hel-1 对多种甲病毒具有广谱活性。在基孔肯雅病毒 (CHIKV) 疾病的临床前小动物模型中，SGC-NSP2hel-1 通过与 nsP2 和 ATP 形成稳定的复合物，减少病毒复制并限制病毒诱导的病变[1]。

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SGC-NSP2hel-1 Chemical Structure

SGC-NSP2hel-1 Chemical Structure

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Customer Review

SGC-NSP2hel-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SGC-NSP2hel-1 is a potent, specific and orally active inhibitor of the nsP2 helicase with a CC50 > 250 µM and Selectivity Index of > 4000. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease[1].

体外研究
(In Vitro)

SGC-NSP2hel-1 (8-point 4 fold dose, daily for 3 days) 在 MRC-5 细胞中对多种甲病毒有抑制作用，对细胞活力影响极小，CC50 大于 250 µM，选择性指数大于 4000[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SGC-NSP2hel-1 相关抗体:
体内研究
(In Vivo)

SGC-NSP2hel-1 (30 mg/kg, p.o., bid) 降低基孔肯雅病毒 (CHIKV) 病毒感染的临床前模型中的病毒复制和疾病发生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CHIKV models of 6-week mice[1]
Dosage: 30 mg/kg
Administration: Orally twice daily and once daily with 100mg/kg 1-ABT, beginning at 12 h prior to infection with CHIKV.
Result: Significantly reduced footpad swelling and virus replication in the ipsilateral foot and serum.
Significantly decreased virus-induced pathology, with decreased inflammatory cell recruitment and reduced myositis and muscle damage.
Showed no apparent toxicity (body weight and H&E staining).
分子量

474.66

同用名

RA-0188293

Formula

C26H38N2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SGC-NSP2hel-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGC-NSP2hel-1RA-0188293RA0188293RA 0188293Virus ProteaseAlphavirusesCHIKVNon-structural protein 2 (nsP2)Inhibitorinhibitorinhibit

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目录号：
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