2. Autophagy PROTAC Protein Tyrosine Kinase/RTK
  3. ATTECs SHP2
  4. SHP2 ATTEC degrader-1

SHP2 ATTEC degrader-1 是一种 SHP2 的 ATTEC 降解剂，在 PANC-1 细胞系中 1.0 μM 作用 24 h，降解率为 83.31%。SHP2 ATTEC degrader-1 抑制细胞体内外生长。SHP2 ATTEC degrader-1 诱导细胞凋亡 (apoptosis )，增加上皮标志物（E-cadherin）的表达，降低间质标志物（如N-cadherin, Vimentin）的表达(粉色：LC3 配体（HY-174085）；黑色:linker HY-140468;蓝色：SHP2 配体 (HY-174084))。

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SHP2 ATTEC degrader-1 Chemical Structure

SHP2 ATTEC degrader-1 Chemical Structure

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SHP2 ATTEC degrader-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHP2 ATTEC degrader-1 is a SHP2 ATTEC degrader. SHP2 ATTEC degrader-1 has degradation rate of 83.31 at 1.0 μM for 24 h in the PANC-1 cell line. SHP2 ATTEC degrader-1 inhibits cell growth in vivo and in vitro. SHP2 ATTEC degrader-1 induces apoptosis and increases the expression of the epithelial marker ( E-cadherin)， and reduces the expression of interstitial markers (such as N-cadherin, Vimentin) (Pink: LC3 ligand (HY-174085); Black :linker HY-140468; Blue: SHP2 ligand (HY-174084)[1].

分子量

857.97

Formula

C43H51N7O10S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHP2 ATTEC degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP2 ATTEC degrader-1ATTECsSHP2Autophagosome-tethering compoundsSrc homology phosphatase 2PTPN11PANC-1 cellsATTECapoptosisInhibitorinhibitorinhibit

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目录号：
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