SHP2-IN-38 

SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC₅₀ values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4–11 cells proliferation in vitro with IC₅₀ of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish^[1].

SHP2-IN-38 (0-20 μM, 3 days) 对 MV4-11 细胞增殖表现出较强的抑制能力，IC₅₀ 值为 7.90 μM^[1]。

SHP2-IN-38 (20 μM, 24 h) 降低 MV4-11 细胞中 p-ERK 的磷酸化水平^[1]。

SHP2-IN-38 (10-100 μM) 具有两个明显的吸收峰，分别在 320 nm 和 360 nm，其中 360 nm 为最佳激发波长，其在 DMSO 中的最大发射波长为 550 nm，在DMF中的最大发射波长为 540 nm^[1]。

SHP2-IN-38 (20 μM，16 h) 在 HeLa 细胞中具有良好的荧光成像效果^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SHP2-IN-38 (1 h) 在斑马鱼中有良好的荧光成像^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

377.42

C₂₀H₁₅N₃O₃S

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• [1]. Zhang C, et al. Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors. Bioorg Chem. 2025 May 27;163:108635.  [Content Brief]