1. PI3K/Akt/mTOR Autophagy Immunology/Inflammation
  2. mTOR Autophagy Interleukin Related
  3. SI-W052

SI-W052 是一种具有口服活性、脑渗透性和选择性小分子抑制剂,靶向 mTORTEX264。SI-W052 通过抑制 mTOR 磷酸化激活自噬 (autophagy),增强 TEX264 表达促进内质网更新,抑制 LPS 诱导的炎症因子 (TNF-α, IL-6) 的释放。SI-W052 有望用于阿尔茨海默病 (AD) 相关神经炎症的研究。

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SI-W052 Chemical Structure

SI-W052 Chemical Structure

CAS No. : 2572552-60-2

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5 mg ¥2180
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10 mg ¥3500
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. SI-W052 activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer’s disease (AD)-associated neuroinflammation[1].

IC50 & Target

IL-6

 

分子量

434.89

Formula

C20H19ClN2O5S

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SI-W052
目录号:
HY-174066
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