1. Cell Cycle/DNA Damage Apoptosis Epigenetics
  2. Sirtuin Apoptosis
  3. Sirt1/2-IN-2

Sirt1/2-IN-2 (compound hsa55) 是 SIRT1/2 的双重抑制剂,IC50 分别为 1.8 μM (SIRT1) 和 2.4 μM (SIRT2)。 Sirt1/2-IN-2 完全阻断 p53 脱乙酰化,并增加 p53 和 α-微管蛋白乙酰化。 Sirt1/2-IN-2 诱导细胞凋亡并对人白血病细胞系显示出抗增殖活性。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Sirt1/2-IN-2 Chemical Structure

Sirt1/2-IN-2 Chemical Structure

CAS No. : 670267-73-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].

IC50 & Target

IC50: 1.8 μM (SIRT1), 2.4 μM (SIRT2), 65 μM (SIRT3)[1]

体外研究
(In Vitro)

Sirt1/2-IN-2 (compound hsa55) (5 μM; 48 h) 诱导不同肿瘤细胞凋亡,IC50 分别为 13 μM (MV4-11)、11.5 μM (MOLM-13)、34.4 μM (THP1)、27.5 μM (Jurkat)[1]。Sirt1/2-IN-2 (100 μM; 30 min) 会降低 SIRT1SIRT2 蛋白在不同温度下的热稳定性,并且 (25 μM、30 μM; 24 h) 会增加 MOLM-13 细胞中 p53 和 α 微管蛋白乙酰化形式的水平[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

398.46

Formula

C18H14N4O3S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Sirt1/2-IN-2
目录号:
HY-155727
需求量: