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  4. Sulfathiazole (100 µg/mL in acetonitrile)

Sulfathiazole (100 µg/mL in acetonitrile) 

目录号: HY-B0507B
产品使用指南 技术支持

Sulfathiazole (100 μg/mL in acetonitrile) 是一种口服有效、靶向类固醇生成途径的内分泌干扰剂，尤其能增强人肾上腺癌细胞 (H295R) 中 CYP19 的活性，并上调 CYP17、CYP19 和 3β-HSD 的 mRN 表达。Sulfathiazole (100 μg/mL in acetonitrile) 增加 17-雌二醇 (E2) 的产生，对水生生物 (如日本青鳉鱼) 的内分泌具有干扰效应。Sulfathiazole (100 μg/mL in acetonitrile) 也是一种阴极型缓蚀剂，通过在铜表面发生化学吸附和物理吸附，抑制氯离子对铜的侵蚀，降低腐蚀电流密度并使腐蚀电位负移。

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Sulfathiazole (100 µg/mL in acetonitrile) Chemical Structure

Sulfathiazole (100 µg/mL in acetonitrile) Chemical Structure

CAS No. : 72-14-0

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Sulfathiazole (100 µg/mL in acetonitrile) 的其他形式现货产品:

Other Forms of Sulfathiazole (100 µg/mL in acetonitrile):

Sulfathiazole (100 µg/mL in acetonitrile) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulfathiazole (100 μg/mL in acetonitrile) is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole (100 μg/mL in acetonitrile) increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole (100 μg/mL in acetonitrile) is also a cathodic corrosion inhibitor. Sulfathiazole (100 μg/mL in acetonitrile) inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively[1][2][3].

体外研究
(In Vitro)

Sulfathiazole (0.02-20 mg/L；48 h) 在人肾上腺癌细胞 (H295R) 实验中可显著增加 17-雌二醇 (E2) 生成、芳香化酶 (CYP19) 活性及 CYP17、CYP19、3βHSD 等类固醇生成相关基因的 mRNA 表达[1]。
Sulfathiazole 能有效抑制铜在 0.1 M NaCl 溶液中的腐蚀，抑制效率随浓度升高可达 80% 以上[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfathiazole (100 µg/mL in acetonitrile) 相关抗体:

Cell Viability Assay[1]

Cell Line: H295R cells
Concentration: 0.2 mg/L, 2 mg/L
Incubation Time: 48 h
Result: Exposure to 0.2 mg/L and 2 mg/L Sulfathiazole sodium for 48 h upregulated the mRNA expression of CYP17, CYP19, and 3βHSD2, which are key genes involved in the steroidogenic pathway.
体内研究
(In Vivo)

Sulfathiazole (50 mg/L、500 mg/L；水体暴露；每日喂食；14 d) 在雄性日本青鳉鱼 (Oryzias latipes) 模型中可显著提高血浆中 17-雌二醇 (E2) 浓度[1]。
Sulfathiazole (1%；混入纯化饲料；每日摄入) 在断奶期及断奶后不久的 Wistar 和 Osborne-Mendel 品系白化大鼠模型中导致骨髓中多形核中性粒细胞、杆状核细胞和晚幼粒细胞减少，骨骼肌坏死和钙化，肺/冠状动脉/肾动脉钙化或玻璃样变，肝细胞水样变性和局灶性透明坏死，肾上腺皮质细胞透明坏死，甲状腺增生，以及皮下组织、体腔和器官出血[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Japanese medaka (Oryzias latipes), 3-4 months old[1]
Dosage: 50 mg/L, 500 mg/L (water)
Administration: Waterborne exposure with ad libitum feeding of Artemia nauplii twice daily, renewed exposure medium at least three times per week for 14 d
Result: After 14-d exposure, plasma E2 concentrations in male medaka were significantly increased to 1.56 ng/mL (50 mg/L) and 2.06 ng/mL (500 mg/L), which were 1.32-fold and 1.75-fold higher than the control (1.18 ng/mL), respectively.
分子量

255.32

Formula

C9H9N3O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sulfathiazole (100 µg/mL in acetonitrile) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfathiazole (100 µg/mL in acetonitrile)72-14-0AntibioticBacterialInhibitorinhibitorinhibit

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