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FPR Agonist 43 

目录号: HY-19574 纯度: 97.12%
产品使用指南

FPR Agonist 43 (compound 43) 是有效的甲酰基肽受体 1 (FPR1) 和甲酰基肽受体 2 (FPR2)/ALX 双重激动剂。

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FPR Agonist 43 Chemical Structure

FPR Agonist 43 Chemical Structure

CAS No. : 903895-98-7

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1540 In-stock
5 mg ¥1400 In-stock
10 mg ¥2200 In-stock
50 mg ¥8800 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2].

IC50 & Target

FPR1, FPR2/ALX[1]

In Vitro

FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells[1].
FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM)[1].
FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells[2].

Cell Viability Assay[1]

Cell Line: Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors
Concentration: 10-5, 10-3, 0.1, 10, 1000, 105, 107 nM
Incubation Time:
Result: Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50 =11.6±1.9 nM).
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (324.79 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5983 mL 12.9917 mL 25.9835 mL
5 mM 0.5197 mL 2.5983 mL 5.1967 mL
10 mM 0.2598 mL 1.2992 mL 2.5983 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.40 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

384.86

Formula

C₂₀H₂₁ClN₄O₂

CAS No.

903895-98-7

SMILES

O=C(NC1=C(C(C)C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(Cl)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
FPR Agonist 43
目录号:
HY-19574
需求量:

FPR Agonist 43

Cat. No.: HY-19574