2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. TGFβ-IN-2

TGFβ-IN-2 (Compound 9d) 作用于 NRK-49F 细胞，抑制 TGF-β 诱导的总胶原积累，IC50 为 4.31 μM。TGFβ-IN-2 在体外抑制 TGF-β 诱导的 COL1A1、α-SMA 和 p-Smad3 蛋白表达。通过口服给药，TGFβ-IN-2可作为一种有潜力的体内抗纤维化有效化合物。

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TGFβ-IN-2 Chemical Structure

TGFβ-IN-2 Chemical Structure

CAS No. : 2387678-02-4

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TGFβ-IN-2 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration[1].

分子量

378.42

Formula

C22H22N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGFβ-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβ-IN-22387678-02-4TGF-beta/SmadTransforming growth factor betaTGF-βcollagenanti-fibrosisInhibitorinhibitorinhibit

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