2. Apoptosis
  3. Apoptosis
  4. Tigatuzumab

Tigatuzumab  (Synonyms: CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody)

目录号: HY-P99270 纯度: 95.00%
COA

摩尔计算器

Tigatuzumab (CS-1008) 是一种靶向 death receptor 5 (DR5) 的人源 IgG1 单克隆抗体。Tigatuzumab 可诱导癌细胞凋亡，并抑制体内抑制肿瘤生长。Tigatuzumab 可用于癌症研究。

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Tigatuzumab Chemical Structure

Tigatuzumab Chemical Structure

CAS No. : 918127-53-4

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规格 价格 是否有货 数量
1 mg ￥3500
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5 mg ￥9100
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Tigatuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Tigatuzumab 对 MIA PaCa-2 细胞和 BxPC-3 细胞敏感，IC50 值分别为 2.95 和 8.21 μg/mL[1]。
Tigatuzumab (3-8 μg/mL; 5 h) 诱导癌细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tigatuzumab 相关抗体:

Apoptosis Analysis[1]

Cell Line: MIA PaCa-2 and BxPC-3 cell lines
Concentration: 3 and 8 μg/mL
Incubation Time: 5 hours
Result: Induced cell apoptosis, and the methionine restriction increased the caspase activation and apoptosis in pancreatic cancer cells.
体内研究
(In Vivo)

Tigatuzumab (3mg /kg；静脉注射；每周一次，共 4 周) 有效抑制人胰腺癌 MIA PaCa-2-RFP 原位小鼠模型的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with MIA PaCa-2-RFP human pancreatic cancer cells injection[1]
Dosage: 3 mg/kg
Administration: Intravenous injection; 3 mg/kg weekly for 4 weeks
Result: Reduced the tumor volume and decreased the density of viable cancer cells in tumors.
Clinical Trial
分子量

144.6 (kDa)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tigatuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tigatuzumab918127-53-4CS-1008 Anti-Human TRAIL-R2 Recombinant AntibodyCS1008CS 1008Apoptosismonoclonal antibodyapoptosisanti-tumorcancermethionine restrictionInhibitorinhibitorinhibit

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