2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Tisolagiline methylsulfate

Tisolagiline methylsulfate  (Synonyms: KDS2010 methylsulfate)

目录号: HY-127109A
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Tisolagiline methylsulfate (KDS2010) 是一种选择性、可逆且具有口服活性的单胺氧化酶 (MAO-B) 抑制剂，IC50 值为 8 nM。Tisolagiline methylsulfate 具有神经保护和抗神经炎活性。

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Tisolagiline methylsulfate Chemical Structure

Tisolagiline methylsulfate Chemical Structure

CAS No. : 1894207-45-4

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Tisolagiline methylsulfate 的其他形式现货产品:

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Other Forms of Tisolagiline methylsulfate:

Tisolagiline methylsulfate 相关抗体

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查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tisolagiline methylsulfate (KDS2010) is the selective, reversible and orally active inhibitor for MAO-B with an IC50 of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities[1][2].

IC50 & Target[1]

MAO-B

8 nM (IC50)

体外研究
(In Vitro)

Tisolagiline methylsulfate (1 μM, 4 days) 可降低胶质纤维酸性蛋白 (GFAP) 的表达和糖胺聚糖 (CSPG) 的沉积，从而抑制星形胶质细胞活化和星形胶质细胞瘢痕形成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tisolagiline methylsulfate 相关抗体:

Immunofluorescence[2]

Cell Line: Human astrocytes
Concentration: 1 μM
Incubation Time: 4 days
Result: Inhibited the expression of GFAP.
体内研究
(In Vivo)

Tisolagiline methylsulfate（10 mg/kg，口服，每日一次，连用 30 天）可改善小鼠模型中 MPTP (HY-15608) 诱发的帕金森病[1]。
Tisolagiline methylsulfate （10 mg/kg/天，口服，1-7 天）可抑制星形胶质细胞瘢痕形成，从而增加 Doxorubicin (HY-15142) 向胶质母细胞瘤区域的渗透，增加小鼠模型中胶质母细胞瘤的体积[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP-induced Parkinson’s disease in mouse models[1]
Dosage: 10 mg/kg
Administration: po, once daily for 30 days
Result: Alleviated the motor dysfunction, reversed the reduction in the number of TH-positive neurons, reduced the expression of GFAP and iNOS.
Animal Model: U87 MG xenograft mouse models[2]
Dosage: 10 mg/kg
Administration: po for 1-7 days
Result: Increased the fluorescence signal of DOX in the GBM area, increased the volume of GBM tumors.
分子量

418.43

Formula

C18H21F3N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tisolagiline methylsulfate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tisolagiline1894207-45-4KDS2010KDS 2010KDS-2010Monoamine OxidaseMAOInhibitorinhibitorinhibit

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