2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) Bacterial Interleukin Related
  4. TL8-506

TL8-506 (GMP) 是 GMP 级别的 TL8-506 (HY-20457)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。TL8-506 是一种特异性 TLR8 激动剂，EC50 为 30 nM。TL8-506 具有免疫调节的作用，可用于结核病和癌症免疫治疗的研究。

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TL8-506 Chemical Structure

TL8-506 Chemical Structure

CAS No. : 1268163-15-0

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TL8-506 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2].

IC50 & Target[2]

TLR8

30 nM (EC50)

体外研究
(In Vitro)

TL8-506 (1 μM; 18 h) 可激活血液和肿瘤中的树突细胞，诱导促炎细胞因子和趋化因子的分泌，并促进 T 细胞的激活和招募 (TL8-506 与 IFN-γ 或 Poly (I:C) 协同作用)[1]。
TL8-506 能在体外特异性激活 TLR8 转基因小鼠骨髓细胞中的 TLR8[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TL8-506 相关抗体:
体内研究
(In Vivo)

TL8-506 (肌肉注射; 两次; 间隔四周) 在 TLR8 转基因小鼠中，可增强对结核分枝杆菌感染的抵抗能力 (TL8-506 与 ESAT-6、氢氧化铝制成疫苗)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mtb H37Rv treated female TLR8 transgenic mice aged 6 weeks old[2]
Dosage: Twice, four weeks apart
Administration: Intramuscular injection (i.m.); TL8-506 was in form of ESAT6-Alum-TL8-506.
Result: Provided better protection against Mtb challenge compared to ESAT6-Alum. The CFU in the lungs of mice treated with ESAT6-Alum-TL8-506 was significantly lower than that in the ESAT6-Alum group.
Significantly lowered bacterial load in the lungs and livers of mice.
Significantly ameliorated the tuberculous pneumonia and alveolitis and reduced the numbers and the area of granulomas.
Significantly increased the proportion of central memory CD8+ T cells.
分子量

331.37

Formula

C20H17N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TL8-506 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TL8-506 (GMP)1268163-15-0Toll-like Receptor (TLR)BacterialInterleukin RelatedILmycobacterium tuberculosisTLR8 transgenic mousebone marrow cellsdendritic cellsT cellsInhibitorinhibitorinhibit

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目录号：
HY-20457G
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