Trevogrumab  (Synonyms: 曲戈卢单抗; REGN-1033)

Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake^[1][2][3].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Human

Trevogrumab (40 nM，30 分钟) 在人类骨骼肌成纤维细胞中表现出对肌肉生成抑制素 (myostatin) 的强效抑制作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trevogrumab (10 mg/kg，皮下注射，每周两次，持续 4 周) 显著增加了 CB17-SCID 和 C57BL/6 小鼠的肌肉质量和力量^[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

144.04 kDa

曲戈卢单抗; REGN-1033

1429201-24-0

液体

Colorless to light yellow

曲戈卢单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG4 kappa

• 
  Immobilized GDF-8 Protein, Human/Mouse/Rat (HEK293, HY-P72632) can bind Trevogrumab. The EC₅₀ for this effect is 7.74 ng/mL.

• [1]. Masakazu Saitoh, et al. Myostatin inhibitors as pharmacological treatment for muscle wasting and muscular dystrophy. Volume2, Issue1,January 2017,Pages 1-10

  [2]. Mitra A, et al. The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis. Osteoporos Sarcopenia. 2023 Mar;9(1):1-7.  [Content Brief]

  [3]. Latres E, et al. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skelet Muscle. 2015 Oct 9;5:34.  [Content Brief]