2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. VMD-928

VMD-928 是一种具有口服活性，变构，不可逆转的和选择性的原肌球蛋白受体激酶 A (TrkA) 抑制剂。VMD-928 阻断由神经生长因子 (NGF) 与 TrkA 结合引发的下游信号通路，从而抑制细胞增殖、侵袭，促进癌细胞死亡。VMD-928 有望用于多种癌症的研究，包括前列腺癌、胸腺癌、间皮瘤、头颈部鳞状细胞癌、肺癌、卵巢癌、肝细胞癌。

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VMD-928 Chemical Structure

VMD-928 Chemical Structure

CAS No. : 1802770-18-8

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     可免费申领三个不同产品的试用装。

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规格 是否有货
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VMD-928 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

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TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VMD-928 is an orally active, allosteric, irreversible and selective tropomyosin receptor kinase A (TrkA) inhibitor. VMD-928 blocks the downstream signaling pathways triggered by the binding of nerve growth factor (NGF) to TrkA, thereby inhibiting cell proliferation, invasion, and promoting cancer cell death. VMD-928 is promising for research of various cancers, including prostate cancer, thymic carcinoma, mesothelioma, squamous cell carcinoma of the head and neck, squamous cell carcinoma of the lung, ovarian cancer, hepatocellular carcinoma[1][2].

分子量

524.61

Formula

C31H32N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VMD-928 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VMD-9281802770-18-8VMD928VMD 928Trk ReceptorTropomyosin related kinase receptororally activeTrkAcancersInhibitorinhibitorinhibit

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目录号：
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