2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-36

Tubulin polymerization-IN-36 是一种微管蛋白 (tubulin) 聚合抑制剂 (IC50: 2.8 μM)。Tubulin polymerization-IN-36 与微管蛋白的 colchicine 位点结合并抑制 colchicine 的结合。Tubulin polymerization-IN-36 可用于淋巴瘤等癌症的研究。

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Tubulin polymerization-IN-36 Chemical Structure

Tubulin polymerization-IN-36 Chemical Structure

CAS No. : 2011784-91-9

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Tubulin polymerization-IN-36 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas[1].

IC50 & Target

Tubulin polymerization[1]
体外研究
(In Vitro)

Tubulin polymerization-IN-36 (compound 2e, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%[1].
Tubulin polymerization-IN-36 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells[1].
Tubulin polymerization-IN-36 (5 μΜ) inhibits colchicine binding to tubulin by 88%[1].
Tubulin polymerization-IN-36 shows cytotoxicity against MCF-7 cells (IC50: 0.29 μΜ)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-36 相关抗体:

Cell Proliferation Assay[1]

Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells.
Concentration: 0-10 μΜ
Incubation Time: 72 h
Result: Inhibited cell proliferation to 38%, 0.8%, 7.1%, 30.5% at 1 μΜ, respectively.
IC50s: 0.04, 0.02, 0.02, 0.03 μΜ, respectively.

Cell Cycle Analysis[1]

Cell Line: VL51 and MINO cells
Concentration: 50 and 500 nM
Incubation Time: 24, 48 and 72 h
Result: Arrested cell in G2/M phase.
分子量

310.35

Formula

C18H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-36 相关分类

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Keywords:

Tubulin polymerization-IN-362011784-91-9Microtubule/TubulinAntitubulinlymphomacancerVL51MINOMCF-7colchicineInhibitorinhibitorinhibit

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