2. Anti-infection
  3. Parasite
  4. UCB7362

UCB7362 是一种口服有效的抗疟疾 (antimalarial) plasmepsin X (PMX) 抑制剂，其 IC50 为 7 nM。UCB7362 可抑制寄生虫 (parasite) 生长。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

UCB7362 Chemical Structure

UCB7362 Chemical Structure

CAS No. : 3031484-59-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

UCB7362 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC50 of 7 nM. UCB7362 inhibits parasite growth[1].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

UCB7362 is substantially more potent against PMX than PMIX with an IC50 of 7 nM for the former compared to 142 nM for the latter[1].
UCB7362 also demonstrates an improvement in selectivity against Cat D and Renin with an IC50 of 3889 nM and >10,000 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UCB7362 相关抗体:
体内研究
(In Vivo)

UCB7362 (10-60 mg/kg, Oral administration, twice a day, for 4 days) clears parasitemia from peripheral blood[1].
UCB7362 (IV (1 mg/kg), PO (10 mg/kg); once) shows moderate clearance in dog and cynomolgus monkey and moderate-high in rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pf (Plasmodium falciparum) SCID mouse model[1]
Dosage: 10, 25 and 60 mg/kg
Administration: Oral administration, twice a day, for 4 days, with the second administration 10 h after the first one
Result: Cleared parasitemia from peripheral blood in a dose-dependent manner.
Animal Model: Sprague Dawley rat[1]
Dosage: 1 mg/kg, 10 mg/kg
Administration: IV (1 mg/kg), PO (10 mg/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of UCB7362 in Sprague-Dawley rats[1].
IV (1 mg/kg) PO (10 mg/kg)
CL (mL/(min kg)) 43.9
Vss (L/kg) 5.72
Tmax (h) 3
Cmax (nM) 246
AUC0-24 (nM∗h) 793 1410
t1/2 (h) 2.1
F (%) 11
分子量

479.96

Formula

C25H26ClN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UCB7362 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCB73623031484-59-7UCB 7362UCB-7362ParasiteantimalarialPlasmodium falciparumorally activemalarialInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
UCB7362
目录号：
HY-151568
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z