2. Metabolic Enzyme/Protease Apoptosis
  3. PAI-1 Apoptosis
  4. UCD38B hydrochloride

UCD38B hydrochloride 是一种细胞渗透性、竞争性酶促 uPA 抑制剂，其IC50 值为 7 μM。UCD38B hydrochloride 靶向细胞内 uPA，导致 uPA 错误运输到核周线粒体中，降低线粒体膜电位，随后释放凋亡诱导因子 (AIF)。UCD38B hydrochloride 诱导细胞凋亡 (apoptosis)。

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UCD38B hydrochloride Chemical Structure

UCD38B hydrochloride Chemical Structure

CAS No. : 1115177-19-9

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UCD38B hydrochloride 相关抗体

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  • 生物活性

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生物活性

UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis[1][2].

体外研究
(In Vitro)

UCD38B hydrochloride (10-250 μM; 1h) has cell permeant in U87MG cells[1].
UCD38B hydrochloride (10-250 μM; 1h) inhibits cell growth with an IC50 value of 100 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UCD38B hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: U87MG cells
Concentration: 10, 100, and 250 μM
Incubation Time: 24 hours
Result: Inhibited cell growth in a dose-dependent manner.
Formula

C15H16ClN7O3.xHCl
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UCD38B hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

UCD38B1115177-19-9PAI-1ApoptosisPlasminogen activator inhibitor-1cell permeantU87MG celluPAapoptotic inducible factorInhibitorinhibitorinhibit

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