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  4. Veltuzumab

Veltuzumab  (Synonyms: IMMU-106; hA20)

目录号: HY-P99224 纯度: 98.53%
COA

摩尔计算器

Veltuzumab (IMMU-106) 是一种人源化抗 CD20 单克隆抗体。Veltuzumab 在 Daudi 细胞系中的 EC50 值较低，为 0.08-0.09 μg/mL。Veltuzumab 可用于癌症的研究，如非霍奇金淋巴瘤 (NHL)。

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Veltuzumab Chemical Structure

Veltuzumab Chemical Structure

CAS No. : 728917-18-8

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Veltuzumab 相关抗体

Top Publications Citing Use of Products

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Veltuzumab (IMMU-106) is a humanized anti-CD20 monoclonal antibody. Veltuzumab has low EC50 value of 0.08-0.09 μg/mL in the Daudi cell line. Veltuzumab can be used for the research of cancer including non-Hodgkin lymphoma (NHL)[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

EC50: 0.08-0.09 μg/mL (in the Daudi cell line)[1]
体外研究
(In Vitro)

Veltuzumab significantly reduces off-rates in human lymphoma cell lines, as well as increases complement-dependent cytotoxicity in 1 of 3 cell lines, but no other in vitro differences[1].
Veltuzumab (0.001-10 μg/mL, 3 h) has low EC50 value of 0.08-0.09 μg/mL in the Daudi cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Veltuzumab 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: 4 lymphoma cell lines (SU-DHL-6, Daudi, Raji and WSU-FSCCL)
Concentration: 5 μg/mL
Incubation Time: 4 days
Result: Had the sensitivity correlated with CD20 expression (SU-DHL6> Raji > Daudi > WSU-FSCCL).
体内研究
(In Vivo)

Veltuzumab (i.v. or s.c.; 5, 20 and 60 μg; single) can control tumor growth or deplete circulating or sessile B cells at low doses in mouse models of intraperitoneal and subcutaneous doses[1].
Veltuzumab (i.p.; 0.05-35 μg) are significantly effective in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lymphoma xenograft model[1]
Dosage: 5, 20 and 60 μg
Administration: intraperitoneal and subcutaneous, single
Result: Showed low dose of 0.05 μg increased the MST.
Animal Model: SCID mice[1]
Dosage: 0.5, 0.25, 0.1, or 0.05 μg; 35, 3.5, 0.35, or 0.035 μg
Administration: intraperitoneal, single
Result: Improved significantly survival.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Veltuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veltuzumab728917-18-8IMMU-106 hA20IMMU106IMMU 106hA20hA 20hA-20IntegrinCD20monoclonal antibodyDaudi cell linenon-Hodgkin lymphoma (NHL)cancerInhibitorinhibitorinhibit

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