2. Anti-infection
  3. Influenza Virus SARS-CoV
  4. Viral polymerase-IN-1 hydrochloride

Viral polymerase-IN-1 hydrochloride 

目录号: HY-149050
产品使用指南

摩尔计算器

Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine (HY-17026) 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC90 值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2 感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。

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Viral polymerase-IN-1 hydrochloride Chemical Structure

Viral polymerase-IN-1 hydrochloride Chemical Structure

CAS No. : 2367587-02-6

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Viral polymerase-IN-1 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells[1].

IC50 & Target

IC50: 6.4 μM (H1N1) and 5.0 μM (H1N1)[1]
体外研究
(In Vitro)

Viral polymerase-IN-1 hydrochloride (化合物 2h; 0.1, 1, 10 μM; 过夜) 以剂量依赖性方式降低病毒 NP 蛋白表达和病毒 RNA 拷贝[1]。
Viral polymerase-IN-1 hydrochloride (11, 33, 100 μM; 72 小时) 以剂量依赖的方式有效抑制病毒聚合酶活性，从而抑制人细胞 HeLa 中甲型流感病毒 PR8 的聚合酶活性[1]。
Viral polymerase-IN-1 hydrochloride 有效抑制 SARS-CoV-2 感染，在 Calu-3 细胞中 EC50 值为 0.46 μM，CC50 值高于 100 μM，SI 值>217.4[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Viral polymerase-IN-1 hydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: MDCK cells infected PR8 virus
Concentration: 0.1, 1, 10 μM
Incubation Time: Overnight
Result: Reduced viral NP protein expression and viral RNA copies in a dose-dependent manner.
体内研究
(In Vivo)

Viral polymerase-IN-1 hydrochloride (化合物 2h; 5 mg/kg; 腹腔给药; 每天一次; 持续 5 天; 在病毒感染前 4 小时开始) 不仅可以降低小鼠肺部的病毒 RNA 水平，还可以减轻感染介导的肺部浸润[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old BALB/c female mice intranasal infection with maPR8[1]
Dosage: 5 mg/kg
Administration: IP; once daily for 5 days, beginning 4 h prior to virus infection
Result: Alleviated lung damage or reduced viral RNA replication.
分子量

419.77

Formula

C15H16ClF2N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Viral polymerase-IN-1 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Viral polymerase-IN-12367587-02-6Influenza VirusSARS-CoVSARS coronavirusGemcitabineinfluenza Ainfluenza BSARS-CoV-2RNA replicationtranscriptionH1N1 6.4H3N2 5.0Inhibitorinhibitorinhibit

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