2. Inhibitory Antibodies
  3. Vixtimotamab

Vixtimotamab  (Synonyms: AMV-564; TandAb T564)

目录号: HY-P99958 纯度: 97.29%
COA

摩尔计算器

Vixtimotamab (AMV-564; TandAb T564) 是一种双特异性四价串联抗体 (TandAb)，靶向人 CD33 和 CD3 抗原。Vixtimotamab 可用于急性髓系白血病 (AML) 的研究。

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Vixtimotamab Chemical Structure

Vixtimotamab Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥9000
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Vixtimotamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vixtimotamab (AMV-564; TandAb T564) is a bispecific tetravalent tandem diabody (TandAb) that targets human CD33 and human CD3 antigens. Vixtimotamab can be used for the research of acute myeloid leukemia (AML)[1].

IC50 & Target

KD: 0.3 nM (CD33, HL-60 cells), 5.1 nM (CD3, Human T cells)[1]
体外研究
(In Vitro)

Vixtimotamab (TandAb T564; 24 h) 诱导 CD25 和 CD69, EC50 分别为 1 pM 和 2 pM[1]。
Vixtimotamab (TandAb T564; 4 days) 诱导 PBMCs 中的 T 细胞增殖，EC50 为 3 pM[1]。
Vixtimotamab (TandAb T564; 25 pM, 48 h) 显示对 HL-60 和 KG-1a 细胞的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vixtimotamab 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HL-60 and KG-1a cells
Concentration: 25 pM
Incubation Time: 48 h
Result: Showed cytotoxicity of 86.0±1.4% and 81.3±1.5% against HL-60 and KG-1a cells, respectively.
体内研究
(In Vivo)

Vixtimotamab (TandAb T564; 0.1-10 μg/mouse, i.v.; 5 days) 在预防性 HL-60 移植 NOD/scid 小鼠模型中显示剂量依赖性肿瘤生长延迟[1]。
Vixtimotamab (TandAb T564; 50 μg/mouse/d, i.v.; 7 days) 在建立的 HL-60 移植 NOD/scid 小鼠模型中显著抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old NOD/scid female mice, weighing 20.7 ± 1.48 g, prophylactic HL-60 graft model[1]
Dosage: 0.1, 1, or 10 μg/mouse
Administration: Intravenous injection, on days 0, 1, 2, 3, and 4
Result: Demonstrated dose-dependent tumor growth delay.
Clinical Trial
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VixtimotamabAMV-564 TandAb T564AMV564AMV 564TandAb T564TandAb T 564TandAb T-564Othersacute myeloid leukemiaAMLHL-60KG-1aNOD/scidInhibitorinhibitorinhibit

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