2. Immunology/Inflammation
  3. CD3 PSMA
  4. Voxalatamab

Voxalatamab  (Synonyms: 沃昔莱妥单抗; JNJ-63898081; JNJ-081)

目录号: HY-P99517 纯度: 99.90%
COA 技术支持

Voxalatamab (JNJ-63898081) 是一种靶向 PSMA 和 CD3 的双特异性 IgG4 抗体。Voxalatamab 通过激活 T 细胞来攻击表达 PSMA 的肿瘤细胞。Voxalatamab 具有抗癌活性，可用于前列腺癌等实体瘤的研究。

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CAS No. : 2411871-58-2

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规格 价格 是否有货 数量
1 mg ￥7500
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Voxalatamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Voxalatamab (JNJ-63898081) is a bispecific IgG4 antibody targeting PSMA and CD3. Voxalatamab attacks PSMA-expressing tumor cells by activating T cells. Voxalatamab has anticancer activity and is being studied for the treatment of solid tumors such as prostate cancer[1][2].

IC50 & Target

CD3E & FOLH1
体外研究
(In Vitro)

Voxalatamab 可与表达 PSMA 的肿瘤细胞和 CD3 的 T 细胞结合，以克服免疫抑制并促进抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Voxalatamab 相关抗体:
Clinical Trial
基因 ID

916 & 2346  [NCBI]

Accession

P07766 & Q04609
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.68 kDa

同用名

沃昔莱妥单抗; JNJ-63898081; JNJ-081

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

沃昔莱妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Ig(G4-kappa_G4-lambda2)
Biological Activity
  • Immobilized Human CD3 epsilon/CD3e Protein (ECD, His Tag) can bind Voxalatamab. The EC50 for this effect is 4.79 ng/mL.
  • Immobilized Human PSMA/FOLH1 Protein can bind Voxalatamab. The EC50 for this effect is 47.87 ng/mL.
纯度 & 产品资料
参考文献

Voxalatamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Voxalatamab2411871-58-2JNJ-63898081 JNJ-081沃昔莱妥单抗JNJ63898081JNJ 63898081JNJ081JNJ 081JNJ-081CD3PSMACluster of differentiation 3Prostate-specific membrane antigenIgG4anti-cancerprostate cancerInhibitorinhibitorinhibit

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目录号：
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